Adipotide 2mg jekiseni

Adipotide (aka FTPP kana proapototic peptide) inouraya masero emafuta, akajeka uye ari nyore, nekutarisa kupihwa kweropa kweaya maseru.Sezvineiwo, adipotide inokwanisa kuona tsinga dzeropa mumasero emafuta kubva mutsinga dzeropa mukati memuviri wese uye nekudaro inosarudza zvakanyanya.Tsvagiridzo mutsoko inoratidza kuti adipotide haingokonzeredzi kuonda, inotowedzera insulin senitivity uye inobvisa mamwe mhedzisiro yerudzi rwechipiri chirwere cheshuga.

Kushandiswa Kwechigadzirwa: Ichi chigadzirwa CHINORANGWA SEKUTSVAKA CHEMICAL CHETE.Iri zita rinobvumira kushandiswa kwemakemikari ekutsvagisa kune in vitro bvunzo uye murabhoritari kuyedza chete.Ruzivo rwese rwechigadzirwa rwunowanikwa pane ino webhusaiti nderwezvinangwa zvekudzidzisa chete.Kupinza muviri kwerudzi rwupi zvarwo muvanhu kana mhuka kunorambidzwa zvachose nemutemo.Ichi chigadzirwa chinofanirwa kubatwa chete neane rezinesi, nyanzvi dzinokwanisa.Ichi chigadzirwa hachisi chinodhaka, chikafu, kana cosmetic uye hachigone kunyorwa zvisizvo, kushandiswa zvisizvo kana kukanganiswa semushonga, chikafu kana cosmetic.

Sequence: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys—Gly-Gly–(Lys-Leu-Ala-Lys-Leu-Ala-Lys)2
Molecular Formula: C152H252N44O42
Molecular Weight: 2611.41 g/mol

Adipotide yakagadzirwa uye yakaiswa muchikamu I kiriniki miedzo muna 2011 kuti iongorore kugona kwayo kuuraya masero emafuta.Miedzo muRhesus tsoko yakaratidza kuti adipotide inokonzeresa apoptosis mutsinga dzeropa chena adipose tishu (mafuta).Pasina kugovera ropa, masero emafuta akangofa.Mhedzisiro yacho yaive nekukurumidza kurasikirwa uremu, kukurumidza kuderera kwemuviri misa index (BMI), uye yakagadziridza insulin kuramba maitiro.Sezvineiwo, kurapwa neadipotide uye kunotevera kurasikirwa kwemafuta hakuna kungovandudza uremu, asi chaizvoizvo kwakabatsira kuchinja maitiro ekudya.Tsoko dzakarasikirwa nehuremu neadipotide dzakaratidzawo kudzikira kwekudya kwekudya[1].

A. Muzana wekurasikirwa nehuremu mumapoka ekudzora (blue) maringe neavo vanorapwa neadipotide (miyero miviri yakasiyana, inoratidzwa mutsvuku)
B. Percent kuderedzwa muBMI (control versus treatment)

A. Inoratidza shanduko ye insulin zvinodiwa (nzvimbo iri pasi pe curve) yekurapa (tsvuku) uye kutonga (blue) mapoka.Iyo AUC yakaverengerwa kubva kuIVGTT bvunzo.
B. Inoratidza insulinogenic index yepamberi uye mushure mekurapa (tsvuku) uye kutonga (bhuruu) mapoka.Mapoka akarapwa anoratidza kuderera kukuru kwe insulin secretion.
C. Shanduko mukushandiswa kwebhisikiti mukubata (tsvuku) uye kutonga (bhuruu) mapoka.

Iyo inonangwa yeadipotide kumidziyo yeropa inoshandira masero emafuta inogona kuyananiswa neprotein receptor inonzi prohibitin.Prohibitin ipuroteni ye membrane inogona kungowanikwa mumidziyo yeropa inoshumira mafuta machena uye mumasero ekenza.Zvakaratidzwa kuti adipotide inoshamwaridzana neprotein iyi[2].Kana zvikazoitika kuti prohibitin inowanikwa chete mumafuta evasculature uye cancer tishu, ipapo kuongororwa kweadipotide kuchava nebasa rekuona mafuta-chaiwo chinangwa chinogona kushandiswa kwete nekuda kwekurapa chete, asi nekuda kwekuongorora zvakare.