Yakakwira Kureruka Kwehuremu paTirzepatide Zvinobatanidza kune Zvinomwe Zvinhu

Pakati pevanhu 3188 vane chirwere cheshuga chechipiri avo vaiomerera kune yavo tirzepatide (Mounjaro, Lilly) mumatambudziko mana anokosha emumiririri, chikamu chechina chakawana chidimbu che15% kubva pahutano hwavo hwekutanga mushure memavhiki e40-42 ekurapwa, uye vatsvakurudzi vakawana minomwe yekutanga yakasiyana-siyana yakanyatsobatanidzwa nehuwandu hwehuwandu hwehuwandu hwekureruka.

"Izvi zvakawanikwa zvinobatsira kuzivisa kuti ndevapi vanhu vane Type 2 chirwere cheshuga vanogona kuwana hukuru hwekudzikisa uremu nekuvandudzwa kwe cardiometabolic ngozi ne tirzepatide," vanodaro vanyori.

MITIRO:

• Vaongorori vakaita post hoc ongororo yedata yakaunganidzwa kubva kuhuwandu hwevanhu mazana matatu nemakumi masere nevasere vane chirwere cheshuga cherudzi rwechipiri vanga vachitevedzera chirongwa chavo chetirzepatide kwemavhiki makumi mana kusvika makumi mana nemaviri mune chero ipi zvayo yemiedzo ina yakakosha yemumiririri: SURPASS-1, SURPASS- 2, SURPASS-3, uye SURPASS-4.
• Vatsvakurudzi vane chinangwa chekuziva kufungidzira kwekuderedzwa kwehuremu hwehuremu hunosvika 15% nekurapa kwetirzepatide pane chero ipi zvayo mitatu yakaedzwa doses - 5 mg, 10 mg, kana 15 mg - iyo yaishandiswa nejekiseni re subcutaneous kamwe pavhiki.
• Miedzo mina yose yakapa data yakarambidza kurapa panguva imwechete iyo yaizokurudzira kuonda, uye vanhu vakabatanidzwa mukuongorora havana kugamuchira chero mishonga yekununura yekudzora glycemia.
• Chiyero chekutanga chekushanda muzvidzidzo zvina kwaiva kukwanisa kwetirzepatide kuvandudza glycemic control (yakayerwa neA1c level) kana ichienzaniswa ne placebo, semaglutide (Ozempic) 1 mg SC kamwe chete pavhiki, insulin degludec (Tresiba, Novo Nordisk), kana insulin glargine ( Basaglar, Lilly).

TORA WOENDA NAZVO:

• Pakati pevanhu 3188 vakaramba vakaomerera kuchirongwa chavo chetirzepatide kwemavhiki e40-42, 792 (25%) vakawana kuderedza uremu kweinenge 15% kubva pakutanga.
• Multivariate kuongororwa kwekutanga covariates kwakaratidza kuti zvinhu zvinomwe izvi zvakabatanidzwa zvakanyanya ne ≥15% kurasikirwa uremu: yakakwira tirzepatide dose, kuve mukadzi, kuve weWhite kana Asia rudzi, kuve wezera diki, kurapwa nemetformin, kuve nepamusoro glycemic control (yakavakirwa pane yakaderera A1c uye yakaderera yekutsanya serum glucose), uye ine yakaderera isiri-yakakwirira-density lipoprotein cholesterol level.
• Munguva yekutevera, kubudirira kweinenge 15% kuchekwa kwekutanga kwehuremu hwemuviri kwakabatana zvakanyanya nekuderera kukuru muA1c, kutsanya serum glucose level, chiuno circumference, blood pressure, serum triglyceride level, uye serum level yechiropa enzyme alanine transaminase. .
  

  KUITA:

  "Izvi zvakawanikwa zvinogona kupa ruzivo rwakakosha kuvarapi uye vanhu vane chirwere cheshuga cherudzi rwechipiri nezve mukana wekudzikisa huremu hwemuviri netirzepatide, uye zvakare kubatsira kuratidza kuvandudzwa kungangoonekwa mumhando dzakasiyana dze cardiometabolic risk parameter ine tirzepatide-induced weight loss. ,” vanyori vakagumisa kudaro mumushumo wavo.