Chii chinonzi S-4 (Andrarine)

S-4, yakatengeswa seandarine, is an olly bioavailable, non-steroidal selective androgen receptor modulator (SARM).Andarine inhengo yeagonist ye androgen receptor.

S-4 semamwe maSARMS akagadzirwa mukutanga kwe2000s, mukuedza kukurira miganhu ye pharmacologic uye pharmacokinetic ye steroidal androgen receptor agonists (kureva, testosterone uye DHT), iyo yakaziva kushamwaridzana nechiropa uye chirwere chemwoyo.

Compound S-4 yakashandiswa muzvidzidzo zvemhuka asi yakasiiwa pamberi peyese Phase I yemunhu yemakiriniki miedzo, nekuda kwekusaona.Izvi zvinoitika sezvo S-4 molecule inosunga kune zvinogamuchirwa muziso;kunyanya kusungirirwa kwehasha, kunowedzera kusagadzikana kunowanikwa.Kuvhiringika kwekuona kwakaonekwa kuve kwakajairika, nekuda kwekusiyana kwemakanika chiito, chemushonga zvekuti miedzo yakasiiwa.

Zvinoita SeiS4Andarine Work

Imwe yedzakarongwa nzira dzeS4, ndeyekuti inovhara zvachose kusungwa kweDHT.Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone kana stanolone) inonzi endogenous androgen sex hormone.Zvichienderana ne testosterone, DHT inonyanya kusimba senge agonist ye androgen receptor.

S-4 ine yakakwira androgen receptor (AR) inosunga hukama.Zvidzidzo zvakaratidza kuti S-4 haina simba uye inoshanda kupfuura testosterone propionate (TP) mubasa re androgenic, asi basa ravo revanabolic rakanga rakafanana kana rakakura kudarika reTP.

S-4 izere androgen receptor agonist mune tsandanyama tishu, uye chikamu agonist muprostate.Nokudaro, S-4 inokurudzira zvakasimba kukura kwemhasuru, asi haikwanise kuchengetedza saizi yeprostate.Testosterone inokurudzira tsandanyama uye kukura kweprostate kusvika pamwero wakafanana.S-4 inokonzera yakakosha luteinizing hormone (LH) kana follicle inokurudzira hormone kudzvinyirira.

S-4 (andarine) Benefits

Kunyange zvazvo zvidzidzo zvakawanda zvekuongorora zvakaitwa, kutsvagisa kwakawanda kuri kuenderera mberi uye mumatanho ekutanga ebudiriro.Kuvandudzwa kweSARMS yekushandiswa kwekliniki uye yekurapa seimwe nzira ye androgen, iri kuvimbisa kubva pane preclinical data.

Kusiyana nevanabolic steroids, iyo inosunga kune androgen receptors muzvikamu zvakawanda mumuviri wose, maSARM ega ega anosarudza kusunga kune androgen receptors mune mamwe matishu, asi kwete mune mamwe.Zvakadaro, ivo vachiri kuratidza androgenic uye anabolic mhedzisiro.

SARMS haisi anabolic steroids;asi, iwo ma-synthetic ligands anosunga kune androgen receptors.Zvichienderana nechimiro chavo chemolecular, vanoita sevanopikisa, vanopikisa chikamu, uye vanopikisa.Ndizvo nenzira yakasarudzwa, iyo SARMS inogadzirisa kana kupindirana ma coregulators uye zvinyorwa zvinyorwa kana kuisa mapuroteni e-cascade kukurudzira basa revanabolic.

Zvidzidzo zvakaratidza S-4 izere androgen receptor agonist mune tsandanyama tishu, uye chikamu agonist muprostate, zvichiita kuti ive mumiriri akakodzera seimwe nzira kune steroidal androgen receptor agonists (kureva, testosterone neDHT), nekuda kwekukanganisa kwakabatana. pachiropa, mwoyo, uye kubereka.

Izvo zvinofanirwa kucherechedzwa, kuti kunyangwe SARMS senge S4 ichiwedzera uyerogen chiitiko, haisi mukwikwidzi anoshanda kune hormone replacement therapy, sezvo isingaite aromatize muEstrogen.